MAITs, MR1 and vitamin B metabolites.

@article{Birkinshaw2014MAITsMA,
  title={MAITs, MR1 and vitamin B metabolites.},
  author={Richard W. Birkinshaw and Lars Kjer-Nielsen and Sidonia B G Eckle and James McCluskey and Jamie Rossjohn},
  journal={Current opinion in immunology},
  year={2014},
  volume={26},
  pages={7-13}
}
αβT-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of innate-like T-cells, can recognise metabolites of vitamin B, when presented by the MHC-related protein, MR1. The semi-invariant MAIT T-cell antigen… CONTINUE READING

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