MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation

@inproceedings{Gibbs2016MAITCR,
  title={MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation},
  author={Anna Gibbs and Edwin Leeansyah and Andrea Introini and Dominic Paquin-Proulx and Klara Hasselrot and Emilia K Andersson and Kristina Broliden and Johan K Sandberg and Annelie Tjernlund},
  booktitle={Mucosal Immunology},
  year={2016}
}
The female genital tract (FGT) mucosa is a critically important site for immune defense against microbes. Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population that recognizes microbial riboflavin metabolite antigens in an MR1-dependent manner. The role of MAIT cells in the FGT mucosa is unknown. Here, we found that MAIT cells and MR1+ antigen-presenting cells were present in the upper and lower FGT, with distinct tissue localization of MAIT cells in endometrium vs… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Antimicrobial activity of mucosal-associated invariant T cells

  • L Le Bourhis
  • Nat. Immunol
  • 2010
Highly Influential
5 Excerpts

MAITcells are licensed through granzyme exchange to kill bacterially sensitized targets

  • A Kurioka
  • Mucosal Immunol
  • 2015

Similar Papers

Loading similar papers…