MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications

@inproceedings{PaquinProulx2017MAITCA,
  title={MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications},
  author={Dominic Paquin-Proulx and Benjamin C Greenspun and Emanuela Avelar Silva Costa and Alu{\'i}sio Augusto Cotrim Segurado and Esper G Kallas and Douglas F Nixon and Fabio Leal},
  booktitle={PloS one},
  year={2017}
}
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develop HAM/TSP. The cellular immune response has been implicated in the development of inflammatory alterations in these patients; however the pathogenic mechanisms for disease progression remain unclear. Furthermore, HTLV-1-infected individuals have an increase… CONTINUE READING
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