MAIT cells and MR1-antigen recognition.

  title={MAIT cells and MR1-antigen recognition.},
  author={Andrew N. Keller and Alexandra J Corbett and Jacinta M. Wubben and James McCluskey and Jamie Rossjohn},
  journal={Current opinion in immunology},
Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector potential. Recent data demonstrates how: vitamin B precursors modulate intracellular trafficking of MR1 and impact on MAIT cell development… CONTINUE READING