MAGI-1 is required for Rap 1 activation upon cell-cell contact and for enhancement of VE-cadherin – mediated cell adhesion


Rap1 is a small GTPase which regulates adherens junction maturation. It remains elusive how Rap1 is activated upon cell-cell contact. We demonstrate for the first time that Rap1 is activated upon homophilic engagement of vascular endothelial cadherin (VE-cadherin) at the cell-cell contacts in living cells and that MAGI-1 is required for VE-cadherin… (More)


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