MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

Abstract

The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a critical role in tumorigenesis. However, the biochemical and cellular functions of this enigmatic family of proteins have remained elusive. Here, we identify really interesting new gene (RING) domain… (More)
DOI: 10.1016/j.molcel.2010.08.029

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