MAG-deficient Schwann cells myelinate dorsal root ganglion neurons in culture.

@article{Carenini1998MAGdeficientSC,
  title={MAG-deficient Schwann cells myelinate dorsal root ganglion neurons in culture.},
  author={Stefano Carenini and Dirk Montag and Melitta Schachner and Rudolf Martini},
  journal={Glia},
  year={1998},
  volume={22 3},
  pages={213-20}
}
The myelin-associated glycoprotein (MAG) has been postulated to play a crucial role during myelin formation. Evidence supporting this hypothesis was provided by infecting rat Schwann cells with a retrovirus expressing MAG antisense RNA; these Schwann cells showed reduced levels of MAG expression and failed to myelinate DRG neurons in vitro. However, when MAG expression was disrupted by generating MAG-deficient mice, normal myelin sheaths were formed in peripheral nerves in vivo. In the present… CONTINUE READING