MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin

@article{Maro2015MADD4PunctinAN,
  title={MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin},
  author={G{\'e}raldine S. Maro and Shangbang Gao and Agnieszka M. Olechwier and Wesley L. Hung and Michael Liu and Engin {\"O}zkan and Mei Zhen and Kang Shen},
  journal={Neuron},
  year={2015},
  volume={86},
  pages={1420-1432}
}
At synapses, the presynaptic release machinery is precisely juxtaposed to the postsynaptic neurotransmitter receptors. We studied the molecular mechanisms underlying this exquisite alignment at the C. elegans inhibitory synapses. We found that the sole C. elegans neuroligin homolog, NLG-1, localizes specifically at GABAergic postsynapses and is required for clustering the GABA(A) receptor UNC-49. Two presynaptic factors, Punctin/MADD-4, an ADAMTS-like extracellular protein, and neurexin/NRX-1… CONTINUE READING
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