MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

@article{Michel2001MAD2HC,
  title={MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells},
  author={Loren Scott Michel and Vasco Liberal and Anupam Chatterjee and Regina Kirchwegger and Boris C. Pasche and William L. Gerald and Max C. Dobles and Peter K. Sorger and Vundavalli V Murty and Robert Benezra},
  journal={Nature},
  year={2001},
  volume={409},
  pages={355-359}
}
The mitotic checkpoint protein hsMad2 is required to arrest cells in mitosis when chromosomes are unattached to the mitotic spindle1. The presence of a single, lagging chromosome is sufficient to activate the checkpoint, producing a delay at the metaphase–anaphase transition until the last spindle attachment is made2. Complete loss of the mitotic checkpoint results in embryonic lethality owing to chromosome mis-segregation in various organisms3,4,5,6. Whether partial loss of checkpoint control… CONTINUE READING
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