MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity.

@article{Li1997MAD2AW,
  title={MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity.},
  author={Yi Li and Carlos M. Gorbea and David Mahaffey and Martin Rechsteiner and Robert Benezra},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 23},
  pages={
          12431-6
        }
}
  • Y. Li, C. Gorbea, +2 authors R. Benezra
  • Published 1997
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Cell cycle progression is monitored by checkpoint mechanisms that ensure faithful duplication and accurate segregation of the genome. Defects in spindle assembly or spindle-kinetochore attachment activate the mitotic checkpoint. Once activated, this checkpoint arrests cells prior to the metaphase-anaphase transition with unsegregated chromosomes, stable cyclin B, and elevated M phase promoting factor activity. However, the mechanisms underlying this process remain obscure. Here we report that… Expand
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