MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.

@article{Mohseni2014MACROD2OM,
  title={MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.},
  author={Morassa Mohseni and Justin Cidado and Sarah Croessmann and Karen Cravero and Ashley M Cimino-Mathews and Hong Yuen Wong and Rob B. Scharpf and Daniel J. Zabransky and Abde M Abukhdeir and Joseph P. Garay and Grace M. Wang and Julia A. Beaver and Rory L. Cochran and Brian G. Blair and David M. Rosen and Bracha Erlanger and Pedram Argani and Paula J. Hurley and Josh D Lauring and Ben Ho Park},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 49},
  pages={17606-11}
}
Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We found MACROD2 is amplified and overexpressed in metastatic tamoxifen-resistant tumors. Transgene overexpression of MACROD2 in breast cancer cell lines results in tamoxifen resistance, whereas RNAi… CONTINUE READING
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