MACF1 gene structure: a hybrid of plectin and dystrophin

@article{Gong2001MACF1GS,
  title={MACF1 gene structure: a hybrid of plectin and dystrophin},
  author={T. -W. L. Gong and Cagri Giray Besirli and M. I. Lomax},
  journal={Mammalian Genome},
  year={2001},
  volume={12},
  pages={852-861}
}
Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We isolated a 19.1-kb cDNA encoding a fourth isoform (MACF1-4) with a unique N-terminus. Instead of an N-terminal actin-binding domain found in the other three isoforms, MACF1-4 has eight plectin repeats. The MACF1 gene is located on human Chr 1p32, contains at least 102 exons, spans over 270 kb, and gives rise to four major isoforms with… CONTINUE READING
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