MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

@article{Stein2009MACC1AN,
  title={MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis},
  author={U. Stein and W. Walther and F. Arlt and H. Schwabe and Janice D. Smith and I. Fichtner and W. Birchmeier and P. Schlag},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={59-67}
}
We identified a previously undescribed gene associated with colon cancer by genome-wide expression analysis in primary and metastatic carcinomas: metastasis-associated in colon cancer-1, MACC1. MACC1 expression in tumor specimens is an independent prognostic indicator of metastasis formation and metastasis-free survival. We show that the gene encoding the hepatocyte growth factor (HGF) receptor, MET, is a transcriptional target of MACC1. MACC1 promotes proliferation, invasion and HGF-induced… Expand
MACC1 expression levels as a novel prognostic marker for colorectal cancer
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