M6P/IGF2R imprinting evolution in mammals.

  title={M6P/IGF2R imprinting evolution in mammals.},
  author={J. Killian and J. Byrd and J. V. Jirtle and B. Munday and M. Stoskopf and R. Macdonald and R. Jirtle},
  journal={Molecular cell},
  volume={5 4},
  • J. Killian, J. Byrd, +4 authors R. Jirtle
  • Published 2000
  • Medicine, Biology
  • Molecular cell
  • Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus… CONTINUE READING
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