M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.

@article{Morgana2013M2PK,
  title={M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.},
  author={Hugh P. Morgana and O FrancisJ. and Reillya and Martin A. Weara and O J.Robert and Neillb and Linda A. Fothergill-Gilmorea and Ted R. Huppb and Malcolm D. Walkinshawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 15},
  pages={
          5881-6
        }
}
We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites. Phenylalanine stabilizes an inactive T-state tetrameric conformer and inhibits M2PYK with an IC50 value of 0.24 mM, whereas thyroid hormone (triiodo-L-thyronine, T3) stabilizes an inactive monomeric form of M2PYK with an IC50 of 78 nM. The allosteric activator fructose-1,6-bisphosphate [F16BP, AC50… CONTINUE READING
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