M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.

@article{Miao2012M2PC,
  title={M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.},
  author={Yimin Miao and Huajun Qin and Riqiang Fu and Mukesh Sharma and Thach V. Can and Ivan F. N. Hung and Sorin Luca and Peter L. Gor'kov and William W. Brey and Timothy A. Cross},
  journal={Angewandte Chemie},
  year={2012},
  volume={51 33},
  pages={
          8383-6
        }
}
Membrane protein structure and function, especially for small membrane proteins, can be highly sensitive to the membrane mimetic environment used for structural characterization, as exemplified by the M2 protein from influenza A virus that has been characterized in liquid crystalline lipid bilayers, detergent micelles and in detergent based crystals.[3–8] Various transmembrane (TM) helical tilt angles, different drug binding sites and amphipathic helix interactions, as well as a lack of… CONTINUE READING

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