M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.

@article{Krneta2017M2polarizedAT,
  title={M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.},
  author={Tamara Krneta and Amy E. Gillgrass and Sophie M. Poznanski and Marianne V. Chew and Amanda J. Lee and Martin Kolb and Ali A Ashkar},
  journal={Journal of leukocyte biology},
  year={2017},
  volume={101 1},
  pages={
          285-295
        }
}
The crosstalk between NK cells and M1 macrophages has a vital role in the protection against infections and tumor development. However, macrophages in the tumor resemble an M2 phenotype, and, at present, their effect on NK cells is less clear. This study investigated whether tumor-associated macrophages (TAMs) have a role in altering NK cell function and phenotype using in vitro cocultures of murine NK cells with peritoneal or bone marrow-derived, M2-polarized macrophages or TAMs isolated from… CONTINUE READING
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