M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder.

@article{Braverman1998M2MR,
  title={M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder.},
  author={Alan S. Braverman and Gary R Luthin and Michael R Ruggieri},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={275 5},
  pages={R1654-R1660}
}
In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats that had their major pelvic ganglion bilaterally removed. Denervation induced both hypertrophy and a supersensitivity of the bladders to agonist. The affinities in control bladders for antagonism of carbachol-induced contractions were consistent with M3-mediated contractions. Affinities in denervated bladders for 4-diphenlacetoxy- N-methylpiperidine… CONTINUE READING

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The M 2 muscarinic acetylcholine receptor contributes to rat urinary bladder contraction . Part 2

  • A. S. Braverman, G. R. Luthin, M. R. Ruggieri
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