M2, A novel myelomonocytic cell surface antigen and its distribution on leukemic cells

@article{Majdic1984M2AN,
  title={M2, A novel myelomonocytic cell surface antigen and its distribution on leukemic cells},
  author={Otto Majdic and Peter Bettelheim and Hannes Stockinger and Werner Aberer and Kristof Liszka and Dieter Lutz and Walter Knapp},
  journal={International Journal of Cancer},
  year={1984},
  volume={33}
}
The selectivity of a novel myelomonocytic cell surface antigen, designated M2, has been assessed in a series of 208 leukemias. The M2 antigen is defined by a monoclonal antibody (VIM‐2) of the IgM class. Its expression within the normal hemopoietic system is restricted to myelomonocytic cells. Lymphocytes, erythrocytes, thrombocytes and their morphologically recognizable precursors are negative. Sixty of the 66 acute myeloblastic leukemias (= 91%) and 28 of the 30 myeloid blast crises of CML… 
Characterization of myeloid leukemias with monoclonal antibodies 3C5 and MY9
TLDR
It is concluded that the use of these two McAb will contribute to the diagnosis and classification of AML and may throw some light to the pathogenesis of biphenotypic acute leukemias, including TdT + AML.
Monoclonal antibodies against myeloperoxidase are valuable immunological reagents for the diagnosis of acute myeloid leukaemia
TLDR
With a monoclonal antibody, directed against myeloperoxidase (MPO), the immunological diagnosis of AML is possible in most cases, and a higher diagnostic sensitivity and specificity for AML was found.
Surface markers in acute non-lymphoid leukemia: Analysis with a panel of 36 monoclonal antibodies
TLDR
The reactivity of a panel of monoclonal antibodies was studied in fifty-four cases of acute myeloid (AML) or undifferentiated (AUL) leukemias, and a heterogeneity of stainings in a same blast population was observed.
Acute leukemia with mediastinal mass, lymphadenopathy, and monocytic precursor cells
Cell marker analysis with monoclonal antibodies (MoAb) as well as differentiation studies with the chemical inducer TPA were used to identify a population of apparently lymphoid cells as monocytic
ESTABLISHMENT AND CHARACTERIZATION OF HUMAN MYELOMONOCYTIC (TYS) AND HISTIOCYTIC (TYH) CELL LINES
TLDR
Two different human monocyte‐histiocyte lineages were established and maintained their characteristics over 28 and 16 months of Passage, respectively.
Diagnostic and Prognostic Relevance of the Immunophenotype in Acute Myelocytic Leukemia
TLDR
Findings indicate that immunophenotype may identify some FAB subtypes, and in some cases the phenotypic profile can provide useful information about the clinical outcome.
Unexpected absence of a myeloid surface antigen (3-fucosyl-N-acetyllactosamine) in promyelocytic leukemia.
TLDR
The phenotype of leukemic promyelocytes thus differs from the majority of normal promYelocytes in this respect.
Reactivity pattern of 'myeloid monoclonal antibodies' with emphasis on MCS-2.
TLDR
The detection of MCS-2 on immature ALL blast cells might indicate a coexpression of lymphoid and myeloid markers on very immature cells, or an abnormal gene expression by malignant cells, and the identification of a so far undetected subclass of acute leukemias.
Immunological Phenotyping of Blood and Bone Marrow Cells From Patients with Myelodysplastic Syndromes
TLDR
There exists only little experience with phenotyping in preleukemic disorders, for example in myelodysplastic syndromes (MDS), and immunological phentyping using MoAbs has become a routine technology for the characterization of leukemic blast cells of acute leukemias.
The nature of blast cells in myelodisplastic syndromes evolving to acute leukaemia
TLDR
The exceptional finding of lymphoid as well as megakaryocytic and myeloid transformations suggests that the target cell for these leukaemias could be a pluripotent stem cell.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Expression of myeloid differentiation antigens on normal and malignant myeloid cells.
A series of monoclonal antibodies have been characterized that define four surface antigens (MY3, MY4, MY7, and MY8) of human myeloid cells. They were derived from a fusion of the NS-1 plasmacytoma
Exposure by desialylation of myeloid antigens on acute lymphoblastic leukemia cells.
TLDR
Surprisingly, this granulocyte-associated antigen was exposed by desialylation not only on malignant myeloid precursor cells but also on common acute lymphoblastic leukemia cells.
Identification by a monoclonal antibody of a glycolipid highly expressed by cells from the human myeloid lineage
TLDR
It was found that MAb HL‐C5 recognizes the same antigenic determinant as MAb WGHS 29‐1, which has been reported to react with glycolipids containing the sugar sequence lacto‐N‐fucopentaose III.
Human Myelomonocytic Differentiation Antigens Defined by Monoclonal Antibodies
TLDR
These monoclonal reagents have made it possible to associate membrane structural features with morphologically identifiable stages of normal myeloid differentiation, and with neoplastic cells that represent a malignant proliferation of a given stage of maturation.
My-1, New Myeloid-Specific Antigen Identified by a Mouse Monoclonal Antibody
TLDR
This monoclonal antibody identified a granulopoietic differentiation antigen (designated My-1) and may prove useful in the subclassification on nonlymphoid leukemia and in the investigation of hematopoiesis.
A monoclonal antibody (WT1) for detecting leukemias of T-cell precursors (T-ALL).
TLDR
The phenotype WT1+ HLA-DR TdT+ appears to be unique to T-ALL and can be used systematically for the differential diagnosis of this poor prognosis subtype of ALL.
Glycophorin a expression in malignant hematopoiesis
TLDR
A monoclonal anti‐human glycophorin A antibody reacted with none of the malignant cells in the 229 tested hematopoietic malignancies, including the 121 nonerythroid acute leukemias, which seems to contradict the earlier observations by L. Andersson and colleagues that a considerable proportion of acute leukaemia express GpA on their surface.
Monoclonal antibodies that detect differentiation surface antigens on human myelomonocytic cells.
TLDR
The production and characterization of several new monoclonal antibodies that recognize differentiation antigens present on human cells of the myelomonocytic lineage are described and their use in the in vitro study of the differentiation pathways of human hemopoietic cells and in the characterization of leukemias is discussed.
Membrane Antigens of Human Myeloid Cells Defined by Monoclonal Antibodies
The development of technology to produce monoclonal antibodies for the immunological detection of cell membrane antigens has been extensively applied to the identification of human lymphocyte cell
Normal and malignant human myelocytic and monocytic cells identified by monoclonal antibodies.
TLDR
Two cytotoxic IgM monoclonal antibodies reactive with human cells of myeloid origin that stains monocytic and nucleated erythrocytic cells and reacts with subsets of acute nonlymphocytic leukemia cells are described.
...
1
2
3
4
...