M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.

@article{Liu2006M1MR,
  title={M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.},
  author={Liwang Liu and Rubing Zhao and Yan Bai and Lee F. Stanish and James E Evans and Michael J. Sanderson and Joseph V. Bonventre and Ann R Rittenhouse},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 45},
  pages={11588-98}
}
Ion channels reside in a sea of phospholipids. During normal fluctuations in membrane potential and periods of modulation, lipids that directly associate with channel proteins influence gating by incompletely understood mechanisms. In one model, M(1)-muscarinic receptors (M(1)Rs) may inhibit both Ca(2+) (L- and N-) and K(+) (M-) currents by losing a putative interaction between channels and phosphatidylinositol-4,5-bisphosphate (PIP(2)). However, we found previously that M(1)R inhibition of N… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Arachidonic acid and ion channels: an update.

British journal of pharmacology • 2008
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.

Current opinion in neurobiology • 2005
View 4 Excerpts
Highly Influenced

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.

Proceedings of the National Academy of Sciences of the United States of America • 1992
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…