M1 and M2 Macrophages: Oracles of Health and Disease.

  title={M1 and M2 Macrophages: Oracles of Health and Disease.},
  author={Charles D. Mills},
  journal={Critical reviews in immunology},
  volume={32 6},
  • C. Mills
  • Published 2012
  • Biology
  • Critical reviews in immunology
The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes cell proliferation and tissue repair. Remarkably, the molecules primarily responsible for these "Fight" (NO) or "Fix" (Ornithine) activities both arise from arginine, and via enzymatic pathways (iNOS and arginase) that down regulate each… 

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