• Corpus ID: 88678261

M.R Sparrow, TmI. Omari, and HmWm Mitehell

  title={M.R Sparrow, TmI. Omari, and HmWm Mitehell},
  author={H. Claudius Mitchell},
Epithelial injury and bronchial hyperresponsiveness are commonly associated with airway disease, and are widely considered to occur as the result of inflammatory changes in the airway wall. Mechanistically, the airway epithelium may influence the sensitivity of the airways to provocative stimuli through its primary function as a cellular barrier between the air and the interstitium, or by liberatimg a variety of bronchoactive mediators, e. g . , lipoxygenase and cyclooxygenase products, nitric… 


The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects.
It is proposed that shedding of epithelial cells occurs along a suprabasal plane and that there is a potential plane of cleavage between the suprapasal and the basal cell layers, which might be more vulnerable to the various insults.
Epithelium-derived inhibitory factor in human bronchus.
Role of the epithelium in airway smooth muscle responses to relaxant agonists.
The results suggest that the epithelial is a relatively weak barrier for lipophilic agents but has a major role as a diffusion barrier to hydrophilic substances.
In vitro modulation of the eosinophil‐dependent enhancement of the permeability of the bronchial mucosa
The results suggest that proteinases may make a significant contribution to the genesis of epithelial injury, whereas leukotrienes do not.
The integrity of the epithelium is a major determinant of the responsiveness of the dog bronchial segment to mucosal provocation.
It is concluded that the impermeable nature of the epithelium acts as a barrier to diffusion of hydrophilic and charged molecules thereby producing large concentration gradients across the airway wall.
The influence of epithelium on the responsiveness of guinea‐pig isolated trachea
  • M. Holroyde
  • Biology, Medicine
    British journal of pharmacology
  • 1986
It is suggested that the supersensitivity produced by removal of the epithelium is not due to the removal of a relaxant factor, but rather to the removed of a permeability barrier, allowing a greater concentration of agonist at the level of the underlying smooth muscle.
A comparison of the effects of polyarginine and stimulated eosinophils on the responsiveness of the bovine isovolumic bronchial segment preparation
Observations suggest that the effect of polyarginine was most likely due to disruption of a diffusion barrier and lack of change in intrinsic muscle sensitivity, which is in line with previous studies of bovine isovolumic bronchial segment preparation.
Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma.
With increased density of eosinophils infiltrated in bronchial mucosa, both the incidence of opening of tight junctions of epithelial ciliary cells and the degree of widening of intercellular spaces in epithelium increased significantly, suggesting that eos inophils are related to damage of the bronchials.
Airway epithelium modulates the responsiveness of porcine bronchial smooth muscle.
In fifth-order bronchi, tissues with epithelium showed a significantly greater degree of fade of the response to sustained electrical stimulation, suggesting both epithelia-derived relaxing and contracting factors may be released in porcine airways.