M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.

@article{Rajaram2017MTH,
  title={M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.},
  author={Murugesan V. S. Rajaram and E. Jonathan Arnett and Abul Kalam Azad and Evelyn Guirado and Bin Ni and Abigail D Gerberick and Li-Zhen He and Tibor Keler and Lawrence J Thomas and William P. Lafuse and Larry S. Schlesinger},
  journal={Cell reports},
  year={2017},
  volume={21 1},
  pages={126-140}
}
Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown. The MR is highly expressed on human macrophages, regulating endocytosis, phagocytosis, and immune responses and mediating Mycobacterium tuberculosis (M.tb) phagocytosis by human macrophages, thereby limiting phagosome-lysosome (P-L) fusion. We identified human MR-associated proteins using phosphorylated and non-phosphorylated MR… CONTINUE READING
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