M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.

@article{Tinel2000MtypeKP,
  title={M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.},
  author={Norbert Tinel and Sylvie Diochot and Inger Lauritzen and Jacques Barhanin and Michel Lazdunski and Marc Borsotto},
  journal={FEBS letters},
  year={2000},
  volume={480 2-3},
  pages={137-41}
}
KCNQ2 and KCNQ3 subunits belong to the six transmembrane domain K+ channel family and loss of function mutations are associated with benign familial neonatal convulsions. KCNE2 (MirP1) is a single transmembrane domain subunit first described to be a modulator of the HERG potassium channel in the heart. Here, we show that KCNE2 is present in brain, in areas which also express KCNQ2 and KCNQ3 channels. We demonstrate that KCNE2 associates with KCNQ2 and/or KCNQ3 subunits. In transiently… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…