M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.

@article{Lezmy2017McurrentIR,
  title={M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.},
  author={Jonathan Lezmy and Maya Lipinsky and Yana Khrapunsky and Eti Patrich and Lia Shalom and Asher Peretz and Ilya A. Fleidervish and Bernard Attali},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 47},
  pages={
          E10234-E10243
        }
}
Alterations in synaptic input, persisting for hours to days, elicit homeostatic plastic changes in the axon initial segment (AIS), which is pivotal for spike generation. Here, in hippocampal pyramidal neurons of both primary cultures and slices, we triggered a unique form of AIS plasticity by selectively targeting M-type K+ channels, which predominantly localize to the AIS and are essential for tuning neuronal excitability. While acute M-current inhibition via cholinergic activation or direct… CONTINUE READING
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