M cell pockets of human Peyer's patches are specialized extensions of germinal centers.

@article{Yamanaka2001MCP,
  title={M cell pockets of human Peyer's patches are specialized extensions of germinal centers.},
  author={Takeshi Yamanaka and A Straumfors and Hugh Craig Morton and Olav Fausa and P E R Brandtzaeg and Inger Nina Farstad},
  journal={European journal of immunology},
  year={2001},
  volume={31 1},
  pages={107-17}
}
M cells in follicle-associated epithelium of Peyer's patches (PP) mediate antigen entrance into the underlying lymphoid tissue. To investigate the functional potential of B cells in this unique microcompartment, the expression of co-stimulatory molecules necessary for B-T cell interaction was examined in histologically normal human PP by three-color immunohistochemistry. In the M cell areas, CD80 / CD86 expression was much more frequent on memory (sIgD(-)CD20(+)) B cells than on naive (sIgD… CONTINUE READING