M-CSF mediates TNF-induced inflammatory osteolysis.

  title={M-CSF mediates TNF-induced inflammatory osteolysis.},
  author={Hideki Kitaura and Ping Zhou and Hyun-Ju Kim and Deborah V Novack and Frederick Ross and Steven L Teitelbaum},
  journal={The Journal of clinical investigation},
  volume={115 12},
TNF-alpha is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine's osteoclastogenic properties. The greater contribution was made, however, by stromal cells that express the osteoclastogenic cytokine M-CSF. TNF-alpha stimulated M-CSF gene expression, in vivo, only in the presence of TNF-responsive stromal cells. M-CSF, in turn, induced the… CONTINUE READING
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