M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes.

@article{Eubank2003MCSFIV,
  title={M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes.},
  author={Tim D. Eubank and Michelle F Galloway and Christine M. Montague and W. James Waldman and Clay B. Marsh},
  journal={Journal of immunology},
  year={2003},
  volume={171 5},
  pages={2637-43}
}
The impact of the immune response in malignancy is poorly understood. While immune cells can destroy transformed cells, the targeting and accumulation of monocytes and macrophages at tumor sites may promote tumor metastases. The growth factor M-CSF is important in promoting monocyte survival. Since M-CSF(-/-) mice are protected against tumor metastases, we hypothesized that M-CSF induced monocytes to produce angiogenic factors that facilitate metastases. In this study we demonstrate that… CONTINUE READING

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