M-CSF and GM-CSF promote alveolar macrophage differentiation into multinucleated giant cells with distinct phenotypes.

@article{Lemaire1996MCSFAG,
  title={M-CSF and GM-CSF promote alveolar macrophage differentiation into multinucleated giant cells with distinct phenotypes.},
  author={Irma Lemaire and H. -S. Yang and Wallace D Lauzon and Nathan Gendron},
  journal={Journal of leukocyte biology},
  year={1996},
  volume={60 4},
  pages={509-18}
}
Multinucleated giant cells (MGC) are a hallmark of granulomatous reactions but the mechanisms that regulate their formation are unknown. To address this issue, we cultured resident alveolar macrophages (AM) from rat lung and examined the effects of defined cytokines on AM differentiation and MGC formation. The presence of MGC was found after 3 days in culture with maximal numbers obtained at 7 days and thereafter (up to 21 days). Macrophage colony-stimulating factor (M-CSF) and granulocyte… CONTINUE READING

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