M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice

@article{RumoreMaton2008MCSFAG,
  title={M-CSF and GM-CSF Regulation of STAT5 Activation and  DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice},
  author={B. Rumore-Maton and Jessica Elf and Nicole S. Belkin and B. Stutevoss and Federica Seydel and Erin Garrigan and Sally A. Litherland},
  journal={Clinical and Developmental Immunology},
  year={2008},
  volume={2008},
  pages={841 - 850}
}
Defects in macrophage colony-stimulating factor (M-CSF) signaling disrupt myeloid cell differentiation in nonobese diabetic (NOD) mice, blocking myeloid maturation into tolerogenic antigen-presenting cells (APCs). In the absence of M-CSF signaling, NOD myeloid cells have abnormally high granulocyte macrophage colony-stimulating factor (GM-CSF) expression, and as a result, persistent activation of signal transducer/activator of transcription 5 (STAT5). Persistent STAT5 phosphorylation found in… CONTINUE READING