M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.

@article{Overmeire2016MCSFAG,
  title={M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.},
  author={Eva Van Overmeire and Beno{\^i}t Stijlemans and Felix Heymann and Jiri Keirsse and Yannick Morias and Yvon Elkrim and Lea Brys and Chlo{\'e} Abels and Qods Lahmar and Can Ergen and Lars Vereecke and Frank Tacke and Patrick de Baetselier and Jo A. van Ginderachter and Damya Laoui},
  journal={Cancer research},
  year={2016},
  volume={76 1},
  pages={35-42}
}
Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate from Ly6C(hi) monocytes. However, the mechanisms regulating the abundance and phenotype of distinct TAM subsets remain unknown. Here, we investigated the role of macrophage colony-stimulating factor… CONTINUE READING