M-81, a new peptide antibiotic produced by Streptomyces griseus subsp. Psychrophilus at moderate temperature.

@article{Yoshida1974M81AN,
  title={M-81, a new peptide antibiotic produced by Streptomyces griseus subsp. Psychrophilus at moderate temperature.},
  author={N. Yoshida and S. Hayashi and Y. Tani and K. Ogata},
  journal={The Journal of antibiotics},
  year={1974},
  volume={27 2},
  pages={
          128-32
        }
}
M-81, a new water-soluble basic peptide antibiotic, was isolated from the culture filtrate of Streptomyces griseus subsp. psychrophilus AKU 2881, which produces cryomycin only at low temperatures. M-81 was produced at 20-37°C, but not below 20°C. M-81 was active against some Gram-positive bacteria. Its antimicrobial spectrum is more limited than those of cryomycin. It darkens at 208°-213°C with decomposition. The LD50 in mice by intraperitoneal injection is more than 300 mg/kg. 
3 Citations
Culture conditions for screening of new antibiotics.
Cryomycin and M-81 production from hexamethylenediamine.

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