M-1/M-2 macrophages and the Th1/Th2 paradigm.

  title={M-1/M-2 macrophages and the Th1/Th2 paradigm.},
  author={Charles Dudley Mills and Kristi Kincaid and Jennifer M. Alt and Michelle J. Heilman and Alison M. Hill},
  journal={Journal of immunology},
  volume={164 12},
Evidence is provided that macrophages can make M-1 or M-2 responses. The concept of M-1/M-2 fomented from observations that macrophages from prototypical Th1 strains (C57BL/6, B10D2) are more easily activated to produce NO with either IFN-gamma or LPS than macrophages from Th2 strains (BALB/c, DBA/2). In marked contrast, LPS stimulates Th2, but not Th1, macrophages to increase arginine metabolism to ornithine. Thus, M-1/M-2 does not simply describe activated or unactivated macrophages, but… CONTINUE READING
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