Müllerian-inhibiting substance type II receptor expression and function in purified rat Leydig cells.

@article{Lee1999MllerianinhibitingST,
  title={M{\"u}llerian-inhibiting substance type II receptor expression and function in purified rat Leydig cells.},
  author={M. M. C. van der Lee and Ching Ching Seah and Peter T. Masiakos and Chantal M Sottas and Frederic I. Preffer and Patricia K Donahoe and David T Maclaughlin and Matthew Philip Hardy},
  journal={Endocrinology},
  year={1999},
  volume={140 6},
  pages={2819-27}
}
Müllerian-inhibiting substance (MIS), a gonadal hormone in the transforming growth factor-beta superfamily, induces Müllerian duct involution during male sexual differentiation. Mice with null mutations of the MIS ligand or receptor develop Leydig cell hyperplasia and neoplasia in addition to retained Müllerian ducts, whereas MIS-overexpressing transgenic mice have decreased testosterone concentrations and Leydig cell numbers. We hypothesized that MIS directly modulates Leydig cell… CONTINUE READING
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