Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products

@article{Curtis2010MllerGD,
  title={M{\"u}ller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products},
  author={Timothy M. Curtis and Ross Hamilton and P.-H. Yong and Carmel Mary McVicar and Alex Berner and Robert Pringle and Kenzo Uchida and Ryozo Nagai and Simon Brockbank and Alan W. Stitt},
  journal={Diabetologia},
  year={2010},
  volume={54},
  pages={690-698}
}
The impact of AGEs and advanced lipoxidation end-products (ALEs) on neuronal and Müller glial dysfunction in the diabetic retina is not well understood. We therefore sought to identify dysfunction of the retinal Müller glia during diabetes and to determine whether inhibition of AGEs/ALEs can prevent it. Sprague–Dawley rats were divided into three groups: (1) non-diabetic; (2) untreated streptozotocin-induced diabetic; and (3) diabetic treated with the AGE/ALE inhibitor pyridoxamine for the… CONTINUE READING

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The N -(3-formyl-3,4dehydropiperidino)lysine adduct plays an important role in Müller glia dysfunction and death in diabetic retinopathy

  • PH Yong, H Zong, R Medina
  • Mol Vis
  • 2010
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