Müller (glial) cell development in vivo and in retinal explant cultures: morphology and electrophysiology, and the effects of elevated ammonia.

@article{Bringmann1998MllerC,
  title={M{\"u}ller (glial) cell development in vivo and in retinal explant cultures: morphology and electrophysiology, and the effects of elevated ammonia.},
  author={Andreas Bringmann and Heidrun Kuhrt and Angela Germer and Bernd Biedermann and Andreas Reichenbach},
  journal={Journal fur Hirnforschung},
  year={1998},
  volume={39 2},
  pages={
          193-206
        }
}
Retinal explant cultures have been established as a useful tool to study both the normal development of the mammalian retina and the effects of pathogenic agents. We used such cultures as a model for the (ammonia-induced) hepatic retinopathy, earlier observed in humans with chronical liver failure, and ascribed to a breakdown of Müller (glial) cell function. In the explant cultures, one day exposure to elevated (7 mM) ammonia was sufficient to cause Müller cell reactivity as indicated by… CONTINUE READING

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