M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.

@article{Nakamura2004M3MA,
  title={M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.},
  author={Takeshi Nakamura and Minoru Matsui and Keiko Uchida and Akira Futatsugi and Shinji Kusakawa and Nagisa Matsumoto and Kyoko Nakamura and Toshiya Manabe and Makoto Mark Taketo and Katsuhiko Mikoshiba},
  journal={The Journal of physiology},
  year={2004},
  volume={558 Pt 2},
  pages={561-75}
}
The M(1) and M(3) subtypes are the major muscarinic acetylcholine receptors in the salivary gland and M(3) is reported to be more abundant. However, despite initial reports of salivation abnormalities in M(3)-knockout (M(3)KO) mice, it is still unclear which subtype is functionally relevant in physiological salivation. In the present study, salivary secretory function was examined using mice lacking specific subtype(s) of muscarinic receptor. The carbachol-induced [Ca(2+)](i) increase was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…