Lytic peptides with improved stability and selectivity designed for cancer treatment.

  title={Lytic peptides with improved stability and selectivity designed for cancer treatment.},
  author={Long Chen and Zhigang Tu and Natalya Voloshchuk and Jun Liang},
  journal={Journal of pharmaceutical sciences},
  volume={101 4},
Lytic peptides are a group of membrane-acting peptides, which have excellent activity to drug-resistant cells. In this study, the stability and tumor selectivity of newly designed pH-activated lytic peptides were studied. We found that despite varied secondary structures, pH-induced structure changes could not be directly linked to the activity and pH sensitivity of peptides. On the contrary, formation of aggregates had great impacts on peptide binding and insertion into the lipid bilayer of… CONTINUE READING

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