Lytic peptides with improved stability and selectivity designed for cancer treatment.

@article{Chen2012LyticPW,
  title={Lytic peptides with improved stability and selectivity designed for cancer treatment.},
  author={Long Chen and Zhigang Tu and Natalya Voloshchuk and Jun Liang},
  journal={Journal of pharmaceutical sciences},
  year={2012},
  volume={101 4},
  pages={
          1508-17
        }
}
Lytic peptides are a group of membrane-acting peptides, which have excellent activity to drug-resistant cells. In this study, the stability and tumor selectivity of newly designed pH-activated lytic peptides were studied. We found that despite varied secondary structures, pH-induced structure changes could not be directly linked to the activity and pH sensitivity of peptides. On the contrary, formation of aggregates had great impacts on peptide binding and insertion into the lipid bilayer of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-5 of 5 extracted citations

Self-assembly nanostructure controlled sustained release, activity and stability of peptide drugs.

International journal of pharmaceutics • 2017
View 10 Excerpts
Highly Influenced

The potential roles of cell surface pHs in bioactive peptide activation.

Chemical biology & drug design • 2015
View 10 Excerpts
Method Support
Highly Influenced

The Effects of Metal Ions on the Cytotoxicity and Selectivity of a Histidine-Containing Lytic Peptide

International Journal of Peptide Research and Therapeutics • 2013
View 5 Excerpts
Method Support
Highly Influenced