Lysyl oxidase modulates the osteoblast differentiation of primary mouse calvaria cells.

@article{SharmaBhandari2015LysylOM,
  title={Lysyl oxidase modulates the osteoblast differentiation of primary mouse calvaria cells.},
  author={Anjali Sharma-Bhandari and Sun-Hyang Park and Ju-Young Kim and Jaemin Oh and Youngho Kim},
  journal={International journal of molecular medicine},
  year={2015},
  volume={36 6},
  pages={
          1664-70
        }
}
Lysyl oxidase (LOX) is an extracellular amine oxidase that mediates the formation of collagen fibers. Thus far, five LOX family genes [LOX, lysyl oxidase-like (LOXL)1, LOXL2, LOXL3 and LOXL4] have been identified in humans, each encoding the characteristic C-terminal domains that are required for amine oxidase activity. During osteoblastogenesis, collagen fibers function as a three-dimensional scaffold for organizing mineral deposition. In this study, to assess the functional roles of the LOX… Expand
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The roles of members of the LOX family in the context of the remodeling of organogenesis and organ development are discussed and the consequences of the malfunction of these proteins related to the development of abnormalities and resulting diseases is discussed. Expand
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