Lysyl oxidase is associated with increased thrombosis and platelet reactivity.

@article{Matsuura2016LysylOI,
  title={Lysyl oxidase is associated with increased thrombosis and platelet reactivity.},
  author={Shinobu Matsuura and Rongjuan Mi and Milka Koupenova and Alexia Eliades and Shenia Patterson and Paul A. Toselli and Jonathan N Thon and Joseph E. Italiano and Philip C Trackman and Nikolaos Papadantonakis and Katya Ravid},
  journal={Blood},
  year={2016},
  volume={127 11},
  pages={
          1493-501
        }
}
Lysyl oxidase (LOX) is overexpressed in various pathologies associated with thrombosis, such as arterial stenosis and myeloproliferative neoplasms (MPNs). LOX is elevated in the megakaryocytic lineage of mouse models of MPNs and in patients with MPNs. To gain insight into the role of LOX in thrombosis and platelet function without compounding the influences of other pathologies, transgenic mice expressing LOX in wild-type megakaryocytes and platelets (Pf4-Lox(tg/tg)) were generated. Pf4-Lox(tg… CONTINUE READING
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