Lysyl oxidase expression and collagen cross-linking during chronic adriamycin nephropathy.

@article{Donato1997LysylOE,
  title={Lysyl oxidase expression and collagen cross-linking during chronic adriamycin nephropathy.},
  author={Alberto Di Donato and Gian Marco Ghiggeri and Marco Di Duca and E Jivotenko and R Acinni and Jonica Campolo and Fabrizio Ginevri and Rosanna G. Gusmano},
  journal={Nephron},
  year={1997},
  volume={76 2},
  pages={192-200}
}
Collagen cross-linking induced by lysyl oxidase has been implicated in liver and lung fibrosis. To define the role of this process in kidney fibrosis, we investigated the renal expression of lysyl oxidase and the content in collagen cross-links at various stages of chronic Adriamycin nephropathy in Sprague-Dawley rats. Lysyl oxidase expression was determined by RT-PCR; collagen pyridinium residues, indicating lysyl oxidase induced cross-links, were evaluated by HPLC. These parameters followed a… CONTINUE READING

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