Lysyl oxidase: properties, regulation and multiple functions in biology.

  title={Lysyl oxidase: properties, regulation and multiple functions in biology.},
  author={Lynda Smith-Mungo and Herbert M. Kagan},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  volume={16 7},
Lysyl oxidase (LO) is a copper-dependent amine oxidase that plays a critical role in the biogenesis of connective tissue matrices by crosslinking the extracellular matrix proteins, collagen and elastin. Levels of LO increase in many fibrotic diseases, while expression of the enzyme is decreased in certain diseases involving impaired copper metabolism. While the three-dimensional structure of the enzyme is not yet available, many of its physical-chemical properties, its novel carbonyl cofactor… CONTINUE READING
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