Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity.

@article{Heikkinen2000LysylH3,
  title={Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity.},
  author={Jorma E Heikkinen and Maija Risteli and Chih-chen Wang and Jaana Latvala and M. Eugenia Rossi and Minna Valtavaara and Raili Myllyl{\"a}},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 46},
  pages={36158-63}
}
Lysyl hydroxylase (EC ) and glucosyltransferase (EC ) are enzymes involved in post-translational modifications during collagen biosynthesis. We reveal in this paper that the protein produced by the cDNA for human lysyl hydroxylase isoform 3 (LH3) has both lysyl hydroxylase and glucosyltransferase (GGT) activities. The other known lysyl hydroxylase isoforms, LH1, LH2a, and LH2b, have no GGT activity. Furthermore, antibodies recognizing the amino acid sequence of human LH3 and those against a… CONTINUE READING

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