Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.

  title={Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.},
  author={Yulong Chen and Masahiko Terajima and Yanan Yang and Li Sun and Young-Ho Ahn and Daniela Paňkov{\'a} and Daniel S Puperi and Takeshi Watanabe and Min Peter Kim and Shanda Haley Blackmon and Jaime Correa Rodriguez and Hui Liu and Carmen Behrens and Ignacio Wistuba and Rosalba Minelli and Kenneth L. Scott and Johannah Sanchez-Adams and Farshid Guilak and Debananda Pati and Nishan Thilaganathan and Alan R. Burns and Chad J Creighton and Elisabeth D. Martinez and Tomasz Żal and Kathryn Jane Grande-Allen and Mitsuo Yamauchi and Jonathan M. Kurie},
  journal={The Journal of clinical investigation},
  volume={125 3},
Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links in cancer is still unclear. Here, we postulated that epithelial tumorigenesis is accompanied by changes in the biochemical type of collagen cross-links. Utilizing resected human lung cancer tissues and a p21CIP1/WAF1-deficient, K-rasG12D-expressing murine metastatic lung… CONTINUE READING
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