Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.

@article{MartnezRevelles2017LysylOI,
  title={Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.},
  author={Sonia Mart{\'i}nez-Revelles and Ana Bel{\'e}n Garc{\'i}a-Redondo and Mar{\'i}a Soledad Avenda{\~n}o and Saray Varona and Teresa Palao and Mar Orriols and Fernanda Roberta Roque and Ana Fortu{\~n}o and Rhian M Touyz and Jos{\'e} {\'A}ngel Mart{\'i}nez-Gonz{\'a}lez and M. Gonz{\'a}lez Salaices and Cristina Mart{\'i}nez Rodr{\'i}guez and Ana Mar{\'i}a Flores Briones},
  journal={Antioxidants & redox signaling},
  year={2017},
  volume={27 7},
  pages={
          379-397
        }
}
AIMS Vascular stiffness, structural elastin abnormalities, and increased oxidative stress are hallmarks of hypertension. Lysyl oxidase (LOX) is an elastin crosslinking enzyme that produces H2O2 as a by-product. We addressed the interplay between LOX, oxidative stress, vessel stiffness, and elastin. RESULTS Angiotensin II (Ang II)-infused hypertensive mice and spontaneously hypertensive rats (SHR) showed increased vascular LOX expression and stiffness and an abnormal elastin structure. Mice… CONTINUE READING
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