Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.

  title={Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.},
  author={Thomas R Cox and Alison Gartland and Janine T Erler},
  journal={Cancer research},
  volume={76 2},
Secondary metastatic cancer remains the single biggest cause of mortality and morbidity across most solid tumors. In breast cancer, 100% of deaths are attributed to metastasis. At present, there are no "cures" for secondary metastatic cancer of any form and there is an urgent unmet clinical need to improve the tools available in our arsenal against this disease, both in terms of treatment, but also prevention. Recently, we showed that hypoxic induction of the extracellular matrix modifying… CONTINUE READING
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