Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding

Abstract

Angiotensin I-converting enzyme (ACE) hydrolyzes numerous peptides and is a critical participant in blood pressure regulation and vascular remodeling. Elevated tissue ACE levels are associated with increased risk for cardiovascular and respiratory disorders. Blood ACE concentrations are determined by proteolytic cleavage of ACE from the endothelial cell… (More)
DOI: 10.1038/srep34913

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@inproceedings{Danilov2016LysozymeAB, title={Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding}, author={Sergei M Danilov and Heinrich Luensdorf and Henry T. Akinbi and Andrew B. Nesterovitch and Yuliya Epshtein and Eleftheria Letsiou and Olga V. Kryukova and Tobias Piegeler and Elena Z. Golukhova and David E. Schwartz and Randall O Dull and Richard D Minshall and Olga A. Kost and Joe G. N. Garcia}, booktitle={Scientific reports}, year={2016} }