Lysosomes in cell death

  title={Lysosomes in cell death},
  author={Maria Eugenia Guicciardi and Marcel Leist and Gregory J. Gores},
For many years apoptosis research has focused on caspases and their putative role as sole executioners of programmed cell death. Accumulating information now suggests that lysosomal cathepsins are also pivotally involved in this process, especially in pathological conditions. In particular, the role of lysosomes and lysosomal enzymes in initiation and execution of the apoptotic program has become clear in several models, to the point that the existence of a ‘lysosomal pathway of apoptosis’ is… CONTINUE READING
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