Lysosome-related organelles: driving post-Golgi compartments into specialisation.

  title={Lysosome-related organelles: driving post-Golgi compartments into specialisation.},
  author={Graça Raposo and Michael S Marks and Daniel F Cutler},
  journal={Current opinion in cell biology},
  volume={19 4},
Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking… CONTINUE READING

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