Lysosome lipid storage disorder in NCTR-BALB/c mice. II. Morphologic and cytochemical studies.

@article{Shio1982LysosomeLS,
  title={Lysosome lipid storage disorder in NCTR-BALB/c mice. II. Morphologic and cytochemical studies.},
  author={Helen Shio and Stanley Fowler and C Bhuvaneswaran and M. D. Morris},
  journal={The American journal of pathology},
  year={1982},
  volume={108 2},
  pages={150-9}
}
Electron-microscopic and cytochemical studies were carried out on tissues of NCTR-BALB/c mice. These mice are affected with a neurovisceral genetic disorder involving excessive tissue accumulation of lipid. Distinctive polymorphic intracellular inclusions, bounded by a membrane and containing lamellated bodies, were found in many cells of liver, spleen, lung, kidney, intestine, lymph nodes, and brain. The inclusions transformed reticuloendothelial cells into massive foam cells. Acid phosphatase… CONTINUE READING
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